#: locale=en
## Action
### URL
WebFrame_9A3E665E_80B3_48AF_41C9_044148AE4BDC.url = http://www.criver.com/customer-service/contact-us/
WebFrame_9A3E665E_80B3_48AF_41C9_044148AE4BDC_mobile.url = http://www.criver.com/customer-service/contact-us/
PopupWebFrameBehaviour_92F6CF1D_8E2F_9EF4_41DA_286F6165C410.url = https://criver.widen.net/s/2rk8rkjpjh/ds-portishead-3d-tour-elisa-masat-shorter-03
PopupWebFrameBehaviour_DC235B9D_D355_F4B3_41E6_03A6E2367F53.url = https://criver.widen.net/s/5scwbr9dzw/ds-portishead-3d-tour-jezrom-self-fordham-shorter-02
PopupWebFrameBehaviour_2D66B238_2DED_6300_41C3_0F473C7FADF9.url = https://criver.widen.net/s/f9vjc7rswb/ds-portishead-3d-tour-lorena-shorter-02
PopupWebFrameBehaviour_2D1A5BDF_2DD3_2106_4192_DF31A3801847.url = https://criver.widen.net/s/fqpfwrbqxs/ds-portishead-3d-tour-lorena-shorter-01
PopupWebFrameBehaviour_C2006414_D34C_B3B1_41D2_310B7776EC6D.url = https://criver.widen.net/s/hh2khfchhm/ds-portishead-3d-tour-elisa-masat-shorter-01
PopupWebFrameBehaviour_2C7F1C1B_2DED_2705_41C4_92D2BF3DD4F1.url = https://criver.widen.net/s/hnzpjpgsfw/ds-portishead-3d-tour-lorena-shorter-03
PopupWebFrameBehaviour_C228CBCC_D37C_F492_41DB_28B2EEB5F5FA.url = https://criver.widen.net/s/jbnzg8gxwn/ds-portishead-3d-tour-henry-leonard-shorter-01
PopupWebFrameBehaviour_C3D9BC26_D374_B391_41CD_6EA8210D583F.url = https://criver.widen.net/s/mq5kbmdtwd/ds-portishead-3d-tour-jezrom-self-fordham-shorter-03
PopupWebFrameBehaviour_C37E9AAC_D35C_5491_41E1_CC59DFDAB84C.url = https://criver.widen.net/s/njlbxdswj8/ds-portishead-3d-tour-jezrom-self-fordham-shorter-01
PopupWebFrameBehaviour_951A9514_8210_A2D3_41DB_E002A596BE1A.url = https://criver.widen.net/s/nvcmqrg6pn/ds-portishead-3d-tour-elisa-masat-shorter-02
PopupWebFrameBehaviour_C35B1142_D374_5596_41E4_31332D48CED8.url = https://criver.widen.net/s/sqx7vj8r5g/ds-3421-john-dallow-portishead
PopupWebFrameBehaviour_2DAE609F_2DF7_DF30_419B_2DB9E7A540C3.url = https://criver.widen.net/s/wqzvvnf8lb/ds-portishead-3d-tour-henry-leonard-shorter-02
PopupWebFrameBehaviour_2C2D32E0_2DFD_E310_41B1_F4569D850394.url = https://criver.widen.net/s/wzszqvcrmv/ds-portishead-3d-tour-henry-leonard-shorter-03
PopupWebFrameBehaviour_2FEC7E69_2DF5_2310_41B5_EE340FBF7336.url = https://criver.widen.net/view/video/z3si7i17ng/DS-3421-Katy-Shoesmith-Portishead.mp4
LinkBehaviour_AA9F57C3_A7EF_4633_41DC_21EC17A93B5E.source = https://www2.criver.com/l/60962/2020-09-01/hg4hdm
LinkBehaviour_AA9F57C3_A7EF_4633_41DC_21EC17A93B5E.source = https://www2.criver.com/l/60962/2020-09-01/hg4hdm
## Media
### Image
imlevel_D43DFBDA_C6AF_9743_418B_B960D0E3C1FB.url = media/popup_A0D6E4DF_87E9_FC74_41DA_D635EE78721A_en_0_0.jpg
imlevel_D43D0BDB_C6AF_9742_41D7_45E28311F0A8.url = media/popup_A0D6E4DF_87E9_FC74_41DA_D635EE78721A_en_0_1.jpg
imlevel_D43D2BDB_C6AF_9742_41B7_3C152186E1A6.url = media/popup_A0D6E4DF_87E9_FC74_41DA_D635EE78721A_en_0_2.jpg
imlevel_D43D3BDB_C6AF_9742_41DB_8A30E45A8CAF.url = media/popup_A0D6E4DF_87E9_FC74_41DA_D635EE78721A_en_0_3.jpg
imlevel_D43D5BDB_C6AF_9742_41CF_AED9D65822EB.url = media/popup_A0D6E4DF_87E9_FC74_41DA_D635EE78721A_en_0_4.jpg
### Popup Image
### Title
panorama_5374D19C_59FC_5C10_41D0_3CE2467BFE80.label = Bioanalysis
panorama_054D11F2_0F5E_2112_41AC_3A34CE853FBA.label = Cell Culture
panorama_1149BE6F_10A6_25C4_418D_43D20FBA03FE.label = Cell Culture
photo_40A63D6E_5299_E988_41C7_A95EC7C2F2D4.label = DS-Portishead-Discovery House-First Aid-0T9A7760
panorama_5374F89E_59FB_AC10_41C9_D11D8D93230F.label = Flow Cytometry
panorama_F88EC5CE_F6B9_81C5_41C6_B5BFF0B919BA.label = Gene Analysis
panorama_53757126_59FC_5C30_41C2_24C36DBF76DB.label = Incucyte
panorama_054E3466_0F5E_6732_4174_48C4B6EF7E61.label = Lab Entrance
panorama_1149A44E_10A6_E5C4_41A8_3A998A3FC5CB.label = Microbiology Corridor
panorama_114EB113_10A6_3F5C_41AF_571EDA466AFD.label = Microbiology Lab
panorama_707EE03C_63EF_7D42_41D4_BA48B95692B9.label = Portishead Facility
panorama_53757950_59FC_6C6F_41C0_783E2E461C8E.label = Radiation
panorama_054E5A7A_0F5E_6313_419A_C5438704BBBA.label = Reception
panorama_054EE6EA_0F5E_6332_41A7_E89542D94344.label = Reception-3
panorama_0BD3AF2E_13A2_2498_4194_984C99CBA037.label = Sample Processing
panorama_53747838_59FB_EC10_41A3_9BE2907C0B5C.label = Sample Receipt
## Popup
### Body
htmlText_1383E8AA_1C57_E02D_41B2_5CA541A79B82.html = Autoclaves are used as a physical method for the disinfection of biological waste, and for the sterilization of media, instruments and lab ware. Waste that might contain bacteria, viruses and other biological material that could be harmful to humans or the outside environment should be inactivated by autoclaving before disposal.
Flow cytometry is a high-throughput, sensitive technique that allows you to measure multiple characteristics of individual cells within heterogenous populations through surface and/or intracellular staining. In infectious diseases, flow cytometry is utilized to measure the response of the immune response to infection, for example, by quantifying immune cell infiltration in the infected tissue and expression of activation markers in those cells. Also, direct detection of microbes (virus, bacterial, fungi, and parasites) in tissue can be accomplished when specific fluorescent molecules/dyes are used.
Flow cytometry is a high-throughput, sensitive technique that allows you to measure multiple characteristics of individual cells within heterogenous populations. Important in immuno-oncology, the effector function of cell subtypes and expression of activation/co-inhibitory markers as well as their killing capability can be characterized to better understand the efficacy and MOA of a new therapeutic.
Flow cytometry is a high-throughput, sensitive technique that allows you to measure multiple characteristics of individual cells within heterogenous populations. Importantly in autoimmune diseases, flow cytometry enables the immunophenotyping of complex immune cell subsets and their effector function by studying receptor and cytokine expression upon antigen stimulation at the single cell level.
Incorporation of tritiated thymidine is used to determine the rate of proliferation allowing the response of cells to be investigated. Tracking this proliferation over time allows for the kinetics of growth to be interrogated. This can be used to determine the ability of potential therapeutics to modulate the response of immune cells.
Our Cold Room is climate controlled using a CO2 air cooling system and control panel.
The Cold Room incorporates an automated Temperature monitoring system to promptly notify users of temperature changes via email and text message alert.
Inside we are able to store large quantities of temperature controlled goods and have designated spaces for Scientific Teams, Studies, Goods In Deliveries and light sensitive products.
Our molecular biology lab can be used to assess modulation of gene expression by a candidate therapeutic in various in vitro and in vivo models of autoimmunity, for example in spinal cord and brain samples in our murine EAE model of multiple sclerosis. Small numbers of genes can be measured by qPCR, or a panel of up to 800 genes can be analysed using NanoString’s nCounter platform along with their Autoimmune Discover or Profiling panels.
Our molecular biology lab can be used to assess modulation of the host response by candidate therapeutics in various models of infectious disease, or to identify compounds capable of targeting bacterial virulence factors or antimicrobial resistance factors. Small numbers of genes can be measured by qPCR, or a panel of up to 800 genes can be analysed using NanoString’s nCounter platform. Viral load can also be measured by qPCR.
Our molecular biology lab is used to assess modulation of gene expression by a candidate therapeutic in various in vitro and in vivo models of cancer, including adoptive transfer and syngeneic tumour models. Small numbers of genes can be measured by qPCR, or targeted transcriptomics of up to 800 genes can be carried out using NanoString’s nCounter platform. Biodistribution of cellular therapies can also be measured by qPCR.
Pre/pro-biotic manipulation of the microbiome can significantly impact the development of autoimmune disease, which can be tested using a range of disease models or in vitro assays. Anaerobic bacteria grow in specialized anaerobic cabinets, then are used to dose animals or be applied to complex ‘2.5D’ multi-cellular tissue culture models. These systems allow clients to gain insight into their therapeutic’s efficacy and better understand their mode of action.
The administration of uranyl nitrate in vivo induces renal dysfunction, which can be used to alter pharmacokinetics of compounds in order to produce similar PK data to that seen in human trials. Radiation levels are monitored using a Geiger–Müller counter when work is taking place.
We have ethical permission to collect anonymized blood samples to allow assessment of cellular function in assays targeting cell types and blood constituents which are labile or intolerant to shipping; such as neutrophils or platelets. Our trained phlebotomists are able to ethically consent donors and collect blood samples into a range of anti-coagulants suitable to the assay of choice. Fresh blood samples are frequently used to validate clinical biomarker assays, mimicking collection, storage, and shipping. This allows us to obtain an understanding of the stability of the cell types and target molecules of interest to determine whether the assay is fit for purpose.
Shipping
ID Report
Batch Release